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2-Phenylacetophenone

Short Description:

Diacetophenones are a kind of important pharmaceutical, flavor and fragrance intermediates. In recent years, they are mainly used in the synthesis of antipyretic, analgesic, anti-inflammatory and estrogen drugs (Estrogen Pharmaceutical Agents). Estrogen mainly plays an endocrine regulation role in the reproductive system of vertebrates, but it also has a very important effect on many non-reproductive system organs, such as bones, liver, cardiovascular system, central nervous system and so on. Diseases related to estrogen mainly include: breast cancer, uterine cancer, colon cancer, Alzheimer’s disease, red fever and some diseases of menopausal women (such as osteoporosis). Recent studies have shown that several types of heterocyclic compounds synthesized from benzophenones are active against cancer cells. These heterocyclic compounds are mainly: Isoflavonoid (Isoflavonoid), azole ring (Azole), imidazole ring (Imi-dazole), thiazole ring (Thiazole), isoxazole ring (Isoxa-zole), pyrazole Rings (Pyrazole), of which the pyrazole ring is the best.


Product Detail

Product Tags

Product Info

CAS NO: 451-40-1
Purity: ≥99%
Formula: C14H12O
Formula Wt: 196.24
Synonym: 1,2-Diphenylethan-1-one; Benzylphenylketone, Deoxybenzoin; Phenylmethylphenylketone; Deoxybenzoin98%; ValdecoxibDeoChemicalbookxyBenzoin(BenzylPhenylKetone); ValdecoxibDeoxyBenzoin(BenzylPhenylKetoneOr; Deoxybenzoin,97%; DIPHENYLETHYLKETONE
Melting Point: 54-55°C
Boiling Point: 320°C
Flash Point: >230°F
Solubility: methanol: 0.1g/mL, clear
Appearance: Crystalline Powder

Shipping and Storage

Store Temp: 2-8°C

Chemical Properties Slightly yellow flaky crystals. Melting point 53-60℃. Soluble in alcohol, ketone, ether, slightly soluble in hot water. Boiling point 320℃. Use Intermediate of triphenylamine. Production MethodPhenylacetic acid is reacted with phosphorus trichloride to make phenylacetyl chloride, and then reacted with benzene in the presence of anhydrous aluminum trichloride. The reaction product is evaporated out of excess benzene under reduced pressure, continue to distill under reduced pressure and collect the fraction at 160℃ (0.67kPa), which is diphenylacetophenone. Diphenylacetophenone is flammable and toxic, avoid contact with skin and eyes, avoid inhalation of dust, lack of specific toxicity data, its toxicity can be referred to acetophenone
Toxicity and environmental impact: diphenylacetophenone is a toxic chemical, to avoid contact with skin and eyes, to avoid inhalation of dust. Mice intravenous LD50: 320 mg/kg, no specific toxicity data except for lethal dose, its toxicity can be referred to acetophenone.
Package, storage and transportation: Packed in 20kg or 50kg cardboard drums lined with plastic film and stored in a cool, dry, well-ventilated place, away from incompatible substances such as strong oxidizers. Transport according to combustible toxic chemicals.


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